Putative Orphan G Protein-Coupled Receptors
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(Updated 08/09/07)

GPCRDB Link/
Receptors

Endogenous Ligand(s)

Articles

 GeneCard Link/
Amino Acids in Protein 		Swiss-Prot or TrEMBL Link/ Molecular Weight of Protein OMIM
Link/ Locus

Human
Homologues
GPR1   [An orphan G protein-coupled receptor, GPR1, acts as a coreceptor to allow replication of human immunodeficiency virus types 1 and 2 in brain-derived cells.] [Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor.] [Senescence-associated genes in normal human oral keratinocytes.] 355 aa 41431 Da 2q33.3  
GPR2 (CCR10) CCL27 (SCYA27 or ESkine), SCYA28 [Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2).] [Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC).] 362 aa

38416 Da

 17q21.1-q21.3
 Known chemokine receptors
GPR3 (ACCA) Sphingosine 1-phosphate (S1P), dihydrosphingosine 1-phosphate (DHS1P) [Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase.] [Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.] [Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.] [Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.] 330 aa 35010 Da 1p36.1-p35
 GPR6 (60%), GPR12 (60%)
GPR4 Protons [Proton-sensing G-protein-coupled receptors.] 362 aa 40982 Da 19q13.2-q13.3 OGR1 (51%)
GPR5 (XCR1 or lymphotactin receptor) SCYC1 (lymphotactin), SCYC2 (XCL2) [Up-regulation of XCR1 expression in rheumatoid joints.] [Identification of single C motif-1/lymphotactin receptor XCR1.] 333 aa 38508 Da 3p21.3  
GPR6 Sphingosine 1-phosphate (S1P), dihydrosphingosine 1-phosphate (DHS1P) [Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.] [Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.] [Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.] 363 aa 37881 Da 6q21-q22.1 GPR3 (60%), GPR12 (60%)

GPR7 (NPBW1 or Neuropeptides B/W receptor type 1)

 Neuropeptide B, Neuropeptide W [The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.] [G Protein Receptors (GPR) 7 and 8 are Expressed in Human Adrenocortical Cells, and their Endogenous Ligands Neuropeptides B and W Enhance Cortisol Secretion by Activating Adenylate Cyclase- and Phospholipase C-dependent Signaling Cascades.] 328 aa 36117 Da 8p22-q21.13 GPR8 (70%)

GPR8 (NPBW2 or Neuropeptides B/W receptor type 2)

 Neuropeptide B, Neuropeptide W [The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.] [G Protein Receptors (GPR) 7 and 8 are Expressed in Human Adrenocortical Cells, and their Endogenous Ligands Neuropeptides B and W Enhance Cortisol Secretion by Activating Adenylate Cyclase- and Phospholipase C-dependent Signaling Cascades.] 333 aa 36903 Da 20q13.3 GPR7 (70%)
GPR9 (CXCR3) [Splice variants: CXCR3-A & CXCR3-B] CXCL9 (Mig), CXCL10 (IP-10), CXCL11 (I-TAC), CXCL4 (PF4) [The latter only exhibits high affinity for the CXCR3-B splice variant] [An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4.] [CXCR3-binding chemokines: novel multifunctional therapeutic targets.] [Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization.] 368 aa 40660 Da Xq13 IL8RB (38%, 53% TM), IL8RA (36%, 51% TM)
GPR10 (PrRPR or Prolactin-releasing peptide receptor) Prolactin-releasing peptide (PrRP) [Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor.] [Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors.] 370 aa 41107 Da 10q26.13 NPY1R (31%, 46% TM)
GPR11 (PAR2 or Proteinase-activated receptor 2) Trypsin and trypsin-like serine proteases [Proteinase-activated Receptor 2 (PAR2): a challenging new target for treatment of vascular diseases.] [Protease-Activated Receptors: New Concepts in Regulation of G Protein-Coupled Receptor Signaling and Trafficking] [International Union of Pharmacology. XXVIII. Proteinase-Activated Receptors]
397 aa 44126 Da 5q13  
GPR12 (GPCR21)

Sphingosylphosphorylcholine, Sphingosine 1-phosphate (S1P), dihydrosphingosine 1-phosphate (DHS1P)

[Role of the G-Protein-Coupled Receptor GPR12 as High-Affinity Receptor for Sphingosylphosphorylcholine and Its Expression and Function in Brain Development] [Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors.] [Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.] [Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.]

334 aa 36730 Da 13q12 GPR3 (60%), GPR6 (60%)
GPR13 (CX3CR1) CX3CL1 (fractalkine)

[Fractalkine in vascular biology: from basic research to clinical disease.] [Two Novel Fully Functional Isoforms of CX3CR1 Are Potent HIV Coreceptors]

 355 aa 40396 Da 3p21.3 CCR1 (40%)
GPR14 (UTS2R or Urotensin II receptor) Urotensin II-related peptide, Urotensin II [Urotensin II-related peptide, the endogenous ligand for the urotensin II receptor in the rat brain.] [Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists.] 389 aa 42130 Da 17q25.3 SSTR4 (27%, 41% TM)
GPR15 (Bob)   [A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.] [ Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy.] 360 aa 40787 Da 3q11.2-q13.1  
GPR16 (BLT1 or Leukotriene B4 receptor 1) Leukotriene B4 [International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors] [Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2.] 352 aa 37557 Da 14q11.2-q12
 BLT2 (45.2%)
GPR17   [A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21.] 367 aa 40989 Da 2q21  
GPR18   [Cloning and chromosomal localization of a gene (GPR18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis.] 331 aa 38062 Da 13q32  
GPR19   [Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells.] [The orphan G-protein-coupled receptor GPR19 is expressed predominantly in neuronal cells during mouse embryogenesis.] [Identification of signal transduction pathways used by orphan g protein-coupled receptors.] 415 aa 47701 Da 12p12.3  
GPR20   [Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.] 358 aa 38406 Da 8q24.2-q24.3  
GPR21   [Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.] [Identification of signal transduction pathways used by orphan g protein-coupled receptors.]
349 aa 39515 Da 9q33  
GPR22   [Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.] 433 aa 49319 Da 7q22-q31.1  
GPR23 (LPA4) Lysophosphatidic acid [Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.] [Cloning of a human heptahelical receptor closely related to the P2Y5 receptor.]
370 aa 41895 Da Xq13-q21.1  
GPR24 (MCH1) Melanin-concentrating hormone [Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist.] [Characterization of a human gene related to genes encoding somatostatin receptors.] 422 aa 45963 Da 22q13.2 All 5 SSTR receptors (40% TM)
GPR25   [Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1.] 361 aa 38779 Da 1q32.1 GPR15 (30%, 41% TM), AT2 (27%, 38% TM), SSTR5 (33%, 34 % TM)
GPR26   [Cloning and characterization of additional members of the G protein-coupled receptor family.] [Identification of signal transduction pathways used by orphan g protein-coupled receptors.] 337 aa 37604 Da 10q26.2-q26.3 GPR78 (56% TM)
GPR27   [Discovery of three novel G-protein-coupled receptor genes.] 375 aa 39818 Da 3p21-p14  
GPR28 (CCR9) CCL25 (TECK) [Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.] 357 aa 40713 Da 3p21.3  
GPR29 (CCR6) CCL20 (MIP-3alpha) [Molecular characterization of CCR6: involvement of multiple domains in ligand binding and receptor signaling.] 374 aa 42494 Da 6q27  
GPR30 17Beta-estradiol [A transmembrane intracellular estrogen receptor mediates rapid cell signaling.] [The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells.] 375 aa 42248 Da 7p22  
GPR31   [Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor.] 319 aa 35075 Da 6q27 GPR109B (33%)
GPR32   [Cloning genes encoding receptors related to chemoattractant receptors.] 356 aa 40087 Da 19q13.3  
GPR33   [GPR33 is a pseudogene]        
GPR34   [Discovery of three novel orphan G-protein-coupled receptors.] [A novel subgroup of class I G-protein-coupled receptors.] 381 aa 43860 Da Xp11.4-p11.3  
GPR35   [Discovery of three novel G-protein-coupled receptor genes.] [Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells.] 309 aa 34141 Da 2q37.3  
GPR37 (Parkin-associated endothelin-like receptor)   [Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library.] [Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor.] 613 aa 67114 Da 7q31 ETB (27%)
GPR37L1 (ETBR2)     481 aa 52829 Da 1q32.1  
GPR38 (MTLR1 or motilin receptor) [Splice variants exist: MTLR1A & MTLR1B] Motilin [Receptor for motilin identified in the human gastrointestinal system.] 412 aa 45344 Da 13q14-q21 GHSR (52%)
GPR39   [Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.] [ Common structural basis for constitutive activity of the ghrelin receptor family.] 453 aa 51329 Da 2q21-q22
 NTS1 (32%), GHSR (27%)

GPR40 (FFAR1 or free fatty acid receptor 1)

 Medium and long chain fatty acids: docosahexaenoic acid (DHA), palmitate, oleate, stearate, linoleate, linolenate, etc. [Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.] [The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids.] [GPR40 gene Arg211His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men.] 300 aa 31457 Da 19q13.1 GPR43 (28%)
GPR41 (FFAR3 or free fatty acid receptor 3) Short chain fatty acids: pentanoate, propionate, butyrate, isobutyrate, formate, etc.

[A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.] [The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.] [Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41] [Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.]

 346 aa 38649 Da 19q13.1 GPR43 (43%), GPR42 (98%)
GPR42  

[A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.] ["A third family member, GPR42, is most likely a recent gene duplication of GPR41 and may be a pseudogene."]

346 aa 38695 Da 19q13.1 GPR1 (98%)
GPR43 (FFAR2 or free fatty acid receptor 2) Short chain fatty acids: pentanoate, propionate, butyrate, isobutyrate, formate, etc. [A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1.] [The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.] [Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.] 330 aa 37144 Da 19q13.1 GPR41 (43%), GPR40 (28%)
GPR44 (CRTH2) Prostaglandin D2 (PGD2), delta12-prostaglandin D2 (delta12-PGD2) [Discovery of three novel orphan G-protein-coupled receptors.] [The second PGD(2) receptor CRTH2: structure, properties, and functions in leukocytes.] [Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2.] [Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.] 395 aa 43240 Da 11q12-q13.3  
GPR45 (human PSP24 alpha)   [Discovery of three novel orphan G-protein-coupled receptors.] [Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.] 372 aa   2q11.1-q12 GPR63 (54%)
GPR48 (LGR4)   [Chromosomal localization of GPR48, a novel glycoprotein hormone receptor like GPCR, in human and mouse with radiation hybrid and interspecific backcross mapping.] [ Molecular characterization of a novel glycoprotein hormone G-protein-coupled receptor.] [Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality.] 951 aa [Length of unprocessed precursor] 104461 Da [MW of unprocessed precursor] 11p14-p13  
GPR49 (LGR5 or HG38)   [Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily.] [Characterization of Two LGR Genes Homologous to Gonadotropin and Thyrotropin Receptors with Extracellular Leucine-Rich Repeats and a G Protein-Coupled, Seven-Transmembrane Region] [Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations.] 907 aa [Length of unprocessed precursor] 99998 Da [MW of unprocessed precursor] 12q22-q23 FSHR (35%), TSHR (35%), LHR (35%)
GPR50 (Melatonin-related receptor)  

[Cloning of a melatonin-related receptor from human pituitary.] [Digging deep--structure-function relationships in the melatonin receptor family.]

 613 aa 66924 Da Xq28 MT1 (45%), MT2 (45%)
GPR51 (GABABR2 or GABA-B receptor subunit 2) GABA [Heterodimerization is required for the formation of a functional GABA(B) receptor.] 941 aa [Length of unprocessed precursor] 105821 Da [MW of unprocessed precursor]    
GPR52   [Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.] 361 aa   1q24 GPR21 (71%), H2 (27%), 5-HT4 (26%)
GPR54 (AXOR12) KiSS-1 [Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates.] [Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54] 398 aa 42610 Da 19p13.3  
GPR55   [Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain.] 319 aa   2q37 P2Y5 (29%), GPR23 (30%), GPR35 (27%), CCR4 (23%)
GPR56 (TM7XN1)   [GPR56, a novel secretin-like human G-protein-coupled receptor gene.] [Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association.] [GPR56 is a GPCR that is overexpressed in gliomas and functions in tumor cell adhesion.] 693 aa [Length of unprocessed precursor] 77738 Da [MW of unprocessed precursor] 16q13 HE6 (32%)

GPR57 (TAAR3 or trace amine associated receptor 3)

   [Cloning and characterization of additional members of the G protein-coupled receptor family.] 343 aa 39065 Da 6q23-q24 GPR58 (59%), TAAR5 (37%), 5-HT4 (30%)
GPR58 (TAAR2 or trace amine associated receptor 2)   [Cloning and characterization of additional members of the G protein-coupled receptor family.] 306 aa 34924 Da   GPR57 (59%), TAAR5 (42%), 5-HT4 (34%)
GPR59 (T2R45 or Taste receptor type 2 member 45) Bitter compounds   299 aa 34278 Da Chr. 12  
GPR60 (T2R40 or Taste receptor type 2 member 40) Bitter compounds   323 aa 36812 Da 7q34  
GPR61   [Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain.] 451 aa 49291 Da 1p13.3  
GPR62   [Identification of four novel human G protein-coupled receptors expressed in the brain.] 368 aa 37629 Da 3p21.1  
GPR63 (human PSP24 beta)

Sphingosine 1-phosphate (S1P), dihydrosphingosine 1-phosphate (DHS1P), dioleoylphosphatidic acid (doPA)

[Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63.] [Identification of four novel human G protein-coupled receptors expressed in the brain.] [Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45.]

 419 aa   6q16.1-q16.3 GPR45 (54%)
GPR64 (HE6)   [Cloning of a human epididymis-specific mRNA, HE6, encoding a novel member of the seven transmembrane-domain receptor superfamily.] [Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility.] [Epididymal G protein-coupled receptor (GPCR): two hats and a two-piece suit tailored at the GPS motif.] 1017 aa [Length of unprocessed precursor] 111492 Da [MW of unprocessed precursor] Xp22.13 GPR56 (32%)
GPR65 Psychosine, protons

[Identification of a molecular target of psychosine and its role in globoid cell formation.] [Identification of T cell death-associated gene 8 (TDAG8) as a novel acid sensing G-protein-coupled receptor.]

 337 aa 39333 Da 14q31-q32.1  
GPR66 (NMU1 or Neuromedin U receptor 1) Neuromedin U [Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U.] [Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.] 426 aa 47350 Da 2q37.1  
GPR67 (GPR49)   [See GPR49]        
GPR68 (OGR1) Sphingosylphosphorylcholine, protons [Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1.] [Proton-sensing G-protein-coupled receptors. ] [Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14.] 365 aa 41077 Da 14q31 GPR4 (51%)
GPR70 (T1R1 or Taste receptor type 1 member 1 L-amino acids (when combined with T1R3 in a heteromer) [An amino-acid taste receptor.] 688 aa [Length of unprocessed precursor] 93074 Da [MW of unprocessed precursor] 1p36.23  
GPR71 (T1R2 or Taste receptor type 1 member 2) Sweet-tasting molecules (when combined with T1R3 in a heteromer) [The receptors for mammalian sweet and umami taste.] 839 aa [Length of unprocessed precursor] 95072 Da [MW of unprocessed precursor] 1p36.13  
GPR72 (GPR83)   [See GPR83]        
GPR73 (PK1 or Prokineticin receptor 1) Prokineticin 2beta, prokineticin 1, prokineticin 2

[Molecular cloning and characterization of prokineticin receptors.] [Identification and Pharmacological Characterization of Prokineticin 2{beta} as a Selective Ligand for Prokineticin Receptor 1.]

393 aa 44770 Da 2p13.1 PK2 (87%), Y2 (33%)
GPR73L1 (PK2 or Prokineticin receptor 2) Prokineticin 2, prokineticin 1 [Molecular cloning and characterization of prokineticin receptors.] [Regulation of prokineticin 2 expression by light and the circadian clock.] 384 aa 43996 Da 20p12.3 PK1 (87%)
GPR74 (NPFF2 or Neuropeptide FF receptor 2) Prolactin-releasing peptide (PrRP), Neuropeptide FF [Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF] [Prolactin Releasing Peptide Has High Affinity and Efficacy at Neuropeptide FF2 Receptors] [Neuropeptide FF receptor 2 (NPFF2) is localized to pain-processing regions in the primate spinal cord and the lower level of the medulla oblongata.] 522 aa 60270 Da 4q13.2-q13.3 Y2 (33%)
GPR75   [Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16.] 540 aa 59358 Da 2p16  
GPR77 (C5L2) Acylation Stimulating Protein (ASP)

[C5L2 is a functional receptor for acylation stimulating protein.] [C5L2, a nonsignaling C5A binding protein.] [Identification of four novel human G protein-coupled receptors expressed in the brain.]

337 aa 36080 Da 19q13.33 C5L1 (49% TM)
GPR78   [Discovery and mapping of ten novel G protein-coupled receptor genes.] 363 aa 39332 Da   GPR26 (56% TM)
GPR79   [GPR79 is a pseudogene]     3q25.32  
GPR80 (OXGR1 or GPR99) alpha-ketoglutarate [GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors.] [ Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.]
 337 aa 38251 Da 13q32.1 P2Y2 (50% TM), P2Y4 (50% TM), P2Y6 (50% TM), CysLT2 (50% TM)
GPR81 (GPR104)   [Discovery and mapping of ten novel G protein-coupled receptor genes.] [Molecular Identification of High and Low Affinity Receptors for Nicotinic Acid] 346 aa 39295 Da 12q24.31 GPR109A (58%), GPR109B (57%)
GPR82   [Discovery and mapping of ten novel G protein-coupled receptor genes.] 336 aa 38409 Da Xp11.4  
GPR83 (GPR72)   [Cloning and chromosomal mapping of the mouse and human genes encoding the orphan glucocorticoid-induced receptor (GPR83).] [ Cloning, expression, and regulation of a glucocorticoid-induced receptor in rat brain: effect of repetitive amphetamine.] 423 aa [Length of unprocessed precursor] 48271 Da [MW of unprocessed precursor] 11q21  
GPR84 (EX33)   [Cloning and expression analysis of a novel G-protein-coupled receptor selectively expressed on granulocytes.] 396 aa 43705 Da 12q13.13  
GPR85 (SREB2)   [An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.] [Gpr85, a novel member of the G-protein coupled receptor family, prominently expressed in the developing mouse cerebral cortex.] [A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain.]
 370 aa 41995 Da 7q31 SREB3 (63%), SREB1 (52%)
GPR86 (P2Y13 or GPR94) ADP [Identification of a novel human ADP receptor coupled to G(i).] [Pharmacological Characterization of the Human P2Y13 Receptor] [Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor.] 333 aa 38440 Da 3q24  
GPR87 (GPR95)   [An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.] 358 aa 41436 Da 3q24  
GPR88 (STRG)   [A novel G-protein-coupled receptor gene expressed in striatum.] 384 aa 40269 Da 1p21.3  
GPR89     455 aa 38484 Da 1p36.13-q31.3  
GPR90   [GPR90 is a mouse gene]        
GPR91 (SUCNR1) Succinate [Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors.] [An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors.] 330 aa 38283 Da 3q24-q25.1  
GPR92 (GPR93)   [Discovery and mapping of ten novel G protein-coupled receptor genes.] 372 aa 41347 Da 12p13.31 P2Y5 (40% TM)
GPR93 (GPR92)   [See GPR92]        
GPR94 (GPR86)   [See GPR86]        
GPR95 (GPR87)   [See GPR87]        
GPR97 (PGR26)   [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.] 549 aa [Length of unprocessed precursor] 60861 Da [MW of unprocessed precursor] 16q13  
GPR98 (VLGR1)   [Sequence similarities between a novel putative G protein-coupled receptor and Na+/Ca2+ exchangers define a cation binding domain.] [ Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system.] [Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II.] 6307 aa [Length of gene product VLGR1b] 692668 Da [MW of gene product VLGR1b] 5q14  
GPR99 (GPR80)   [See GPR80]        
GPR100 (GPCR142) Relaxin 3, bradykinin [Identification and characterisation of GPR100 as a novel human G-protein-coupled bradykinin receptor.] [Identification of Relaxin-3/INSL7 as a Ligand for GPCR142] [Bradykinin B2 and GPR100 receptors: a paradigm for receptor signal transduction pharmacology.] 374 aa 41141 Da 1q22  
GPR101   [Discovery and mapping of ten novel G protein-coupled receptor genes.] 508 aa 56716 Da Xq25-27.1  
GPR102 (TA5 or TRAR5)   [Discovery and mapping of ten novel G protein-coupled receptor genes.] 342 aa 38029 Da 6q23.2  
GPR103 26RFa [Identification and Characterization of a Novel RF-amide Peptide Ligand for Orphan G-protein-coupled Receptor SP9155] [Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity.] [Discovery and mapping of ten novel G protein-coupled receptor genes.] [The G-Protein-Coupled Receptor GPR103 Regulates Bone Formation.] 431 aa 49488 Da 4q27  
GPR104 (GPR81)   [See GPR81]        
GPR105 (P2Y14) UDP-glucose, UDP-galactose, UDP-glucuronic acid, UDP-N-acetylglucosamine

[A G protein-coupled receptor for UDP-glucose.] [Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family.] [ GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function.]

 338 aa 38971 Da 3q21-q25  
GPR106 (LGR8) Relaxin, insulin-like factor 3 (INSL3) [A novel circulating hormone of testis origin in humans.] [Activation of orphan receptors by the hormone relaxin.] [GREAT/LGR8 is the only receptor for insulin-like 3 peptide.] 754 aa 86453 Da 13q13.1 LGR7 (60%)
GPR107 (LUSTR1)   [Hypothetical protein] 300 aa 33385 Da 9q34.11  
GPR108 (LUSTR2)   [Hypothetical protein] 536 aa [Length of partial sequence] 59830 Da [MW of the partial sequence] 19p13.3  
GPR109A (HM74A) Nicotinic acid [high affinity] [Molecular identification of high and low affinity receptors for nicotinic acid.] [Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.] 363 aa 41849 Da 12q24.31 GPR109B (96%)
GPR109B (HM74) Nicotinic acid [low affinity] [Molecular identification of high and low affinity receptors for nicotinic acid.] [Variations in human HM74 (GPR109B) and HM74A (GPR109A) niacin receptors.] 387 aa 44481 Da 12q24.31 GPR109A (96%), GPR31 (33%)
GPR110 (GPCR36 or PGR19)   [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.] 911 aa [Length of unprocessed precursor] 101464 Da [MW of unprocessed precursor] 6p12.3  
GPR111 (PGR20)   [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.] 708 aa 78569 Da 6p12.3  
GPR112   [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.] 2799 aa 300967 Da Xq26.3  
GPR113 (PGR23)  

[Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells.] [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.]

 1079 aa [Length of unprocessed precursor] 116341 Da [MW of unprocessed precursor] 2p23.3  
GPR114 (PGR27)   [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.] 570 aa [Length of unprocessed precursor] 63368 Da [MW of unprocessed precursor] 16q13  
GPR115   [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.] 752 aa 83830 Da 6p12.3  
GPR116   [Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions.] 1346 aa [Length of unprocessed precursor] 149457 Da [MW of unprocessed precursor] 6p12.3  
GPR119 (GPCR2) Lysophosphatidylcholine [Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor.] [Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.] 335 aa 36889 Da Xq25 D1 (27%)
GPR120 (GPR129 or PGR4) Unsaturated long chain free fatty acids [Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.] [Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1.] [Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.] 376 aa 42085 Da 10q23.33  
GPR123   [There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.] 1280 aa 137389 Da 10q26  
GPR124   [There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.] 1331 aa [Length of unprocessed precursor] 141962 Da [MW of unprocessed precursor] 8p12  
GPR125   [There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.] 1321 aa [Length of unprocessed precursor] 146151 Da [MW of unprocessed precursor] 4p15.31  
GPR126   [There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.] 1221 aa [Length of unprocessed precursor] 136636 Da [MW of unprocessed precursor] 6q24.1  
GPR127 (EMR4) N/A

[Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence.] [There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.]

 457 aa [Length of unprocessed precursor] 50903 Da [MW of unprocessed precursor] 19p13.3  
GPR128   [There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.] 797 aa [Length of unprocessed precursor] 88909 Da [MW of unprocessed precursor] 3q12.2  
GPR129   [See GPR120]        
GPR131 (GPBAR1 or BG37 or TGR5 or GPCR19) Bile acids [Identification of membrane-type receptor for bile acids (M-BAR).] [ A G protein-coupled receptor responsive to bile acids.] [Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.] 330 aa 35248 Da 2q35  
GPR132 (G2A) Protons [G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.] [Lysophosphatidylcholine-induced Surface Redistribution Regulates Signaling of the Murine G Protein-coupled Receptor G2A.] 380 aa 42499 Da 14q32.3  
GPR133 (PGR25)   [The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.] [Novel human G-protein-coupled receptors.] 874 aa [Length of unprocessed precursor] 96530 Da [MW of unprocessed precursor] 12q24.33 GPR134 (95%)
GPR134 (5-HT5B) N/A [Human 5-HT5 receptors: the 5-HT5A receptor is functional but the 5-HT5B receptor was lost during mammalian evolution]     2q11-2q13 GPR133 (95%)
GPR135   [Novel human G-protein-coupled receptors.] [ Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.]
 494 aa 51736 Da 14q23.1  
GPR136 (OPN5) Neuropsin (Opn5) [Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.] [Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.] 354 aa 39727 Da 6p12.3 GPR137 (57%)
GPR137   [Novel human G-protein-coupled receptors.] 325 aa     GPR136 (57%)
GPR138   [Novel human G-protein-coupled receptors.] 310 aa      

GPR139 (GPRg1 or PGR3)

  [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] [Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.] 353 aa 40679 Da 16p12.3 GPRg1b (44%)
GPR141 (PGR13)   [Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.] 305 aa 35464 Da 7p14.1  
GPR142   [Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.] 462 aa 51106 Da 17q25.1  
GPR143 (OA1)   [Ocular albinism: evidence for a defect in an intracellular signal transduction system.] [The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis.] 404 aa 43878 Da Xp22.3  
GPR144 (PGR24)   [The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.] 963 aa 104087 Da 9q33.3  
GPR145 (MCH2) Melanin-concentrating hormone [Molecular cloning and functional characterization of MCH2, a novel human MCH receptor.] [ Cloning and molecular characterization of the novel human melanin-concentrating hormone receptor MCH2.] 340 aa 38849 Da 6q16 MCH1 (38%)
GPR146 (PGR8)   [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] 333 aa 36580 Da 7p22.3  
GPR147 (NPFF1) Neuropeptide FF (NPFF), neuropeptide AF (NPAF), neuropeptide SF (NPSF), NPVF-related peptides [Identification and Characterization of Novel Mammalian Neuropeptide FF-like Peptides That Attenuate Morphine-induced Antinociception] [Identification and characterization of two G protein-coupled receptors for neuropeptide FF.] 430 aa 47819 Da 10q21-q22  

GPR148 (PGR6)

   [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] 347 aa 38284 Da 2q21.1  
GPR149 (PGR10)     434 aa [Length of the partial sequence] 47707 Da [MW of the partial sequence] 3q25.2  
GPR150 (PGR11)   [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] 434 aa 46353 Da 5q15  
GPR151 (PGR7)     419 aa 46637 Da 5q32  
GPR152 (PGR5)   [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] 470 aa 50962 Da 11q13.2  
GPR153   [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] 609 aa 65341 Da 1p36.31  
GPR154 (NPSR or Neuropetide S Receptor) Neuropeptide S [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] [Haplotypes of G Protein-coupled Receptor 154 Are Associated with Childhood Allergy and Asthma.] [Characterization of a common susceptibility locus for asthma-related traits.] 371 aa 42687 Da 7p14.3  
GPR155     870 aa 96965 Da 2q31.1  
GPR156 (GABABL or PGR28)     814 aa 89082 Da 3q13.33  
GPR157     335 aa 36623 Da 1p36.22  
GPR158   [The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors] 1212 aa 135211 Da 10p12.1  
GPR159 (CMKOR1 or RDC1)   [A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses.] 362 aa 41523 Da 2q37.3  
GPR160 (GPCR150)     338 aa 39787 Da 3q26.2  
GPR161 (RE2)     529 aa 58559 Da 1q24.2  
GPR162   [Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship.] 588 aa   12p13.31  
GPR167 (MRGE or Mas-related G protein-coupled receptor member E)   [Cloning and expression of MRG receptors in macaque, mouse, and human.] 145 aa [Length of the partial sequence] 15957 Da [MW of the partial sequence] 11p15.4  
GPR168 (MRGF or Mas-related G protein-coupled receptor member F)     343 aa 38171 Da 11q13.3  
GPR169 (MRGG or Mas-related G-protein coupled receptor member G)     54 aa [Length of the partial sequence] 6015 Da [MW of the partial sequence] 11p15.4  
GPR170 (OXE or OXER1 or TG1019) 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) [Identification of a novel human eicosanoid receptor coupled to G(i/o).] 423 aa 45810 Da 2p21  
GPR171 (H963)     319 aa 36754 Da 3q25.1  
GPR172A (GPCR41)     445 aa 45777 Da 8q24.3  
GPR172B (GPCR42)     448 aa 46372 Da 17p13.2  
GPR173 (SREB3)   [An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system.] 373 aa 41481 Da Xp11.22  
GPR174 (FKSG79)     333 aa 38503 Da Xq21.1  
GPR175 (TPRA40)     239 aa 26289 Da 3q21.2  
GPR176 (HB-954)   [cDNA cloning of a putative G protein-coupled receptor from brain.] 515 aa 56998 Da 15q14-q15.1  

GPR179 (Probable G-protein coupled receptor 158-like 1)

   [DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.] 2367 aa 257363 Da 17q21.1  

GPR180 (ITR or intimal thickness- related receptor)

   [Inhibition of Experimental Intimal Thickening in Mice Lacking a Novel G-Protein–Coupled Receptor] 2367 aa 49395 Da 13q32.1  
GPRg1b   [Molecular cloning and characterization of a novel Gq-coupled orphan receptor GPRg1 exclusively expressed in the central nervous system.]     17q25.1 GPRg1 (44%)
ADMR   [Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.] 404 aa 45323 Da 12q13.3  
BAI1   [Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression.] 1584 aa [Length of unprocessed precursor] 173533 Da [MW of unprocessed precursor] 8q24  
BAI2   [Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.] [Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).] 1572 aa [Length of unprocessed precursor] 171142 Da [MW of unprocessed precursor] 1p35  
BAI3  

[Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.] [Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).]

1522 aa [Length of unprocessed precursor] 171491 Da [MW of unprocessed precursor] 6q12  
CCLR2 (CKRX)   [Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.] 344 aa 39529 Da 3p21  
CD97 CD55 (decay-accelerating factor), chondroitin sulfate [Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells.] [The epidermal growth factor-seven transmembrane (EGF-TM7) receptor CD97 is required for neutrophil migration and host defense.] 835 aa [Length of unprocessed precursor] 91841 Da [MW of unprocessed precursor] 19p13  
CELSR1 (FMI2)   [Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse.] [Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter.] 3014 aa [Length of unprocessed precursor] 329486 Da [MW of unprocessed precursor] 22q13.3  
CELSR2   [Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin.] 2923 aa [Length of unprocessed precursor] 317453 Da [MW of unprocessed precursor] 1p21  
CELSR3 (FMI1)   [Protocadherin Celsr3 is crucial in axonal tract development.] 3312 aa [Length of unprocessed precursor] 358257 Da [MW of unprocessed precursor] 3p24.1-p21.2  
CMKLR1 (ChemR23 or Chemokine receptor-like 1) Chimerin [The C-terminal Nonapeptide of Mature Chemerin Activates the Chemerin Receptor with Low Nanomolar Potency] [ Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.] 373 aa 42322 Da 12q24.1  
EBI2   [Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors.] 361 aa 41224 Da 13q32.3  
EMR1   [EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments.] 886 aa [Length of unprocessed precursor] 97625 Da [MW of unprocessed precursor] 19p13.3  
EMR2 Chondroitin sulfate

[The epidermal growth factor–like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans] [Identification of the epidermal growth factor-TM7 receptor EMR2 and its ligand dermatan sulfate in rheumatoid synovial tissue.]

 823 aa [Length of unprocessed precursor] 90506 Da [MW of unprocessed precursor] 19p13.1  
EMR3   [Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils.] 652 aa [Length of unprocessed precursor] 72593 Da [MW of unprocessed precursor] 19p13.1  
ELTD1 (ELT)   [ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily.] 690 aa [Length of unprocessed precursor] 77825 Da [MW of unprocessed precursor] 1p33-p32  
GPRC6A Basic l-alpha-amino acids: L-Arg, L-Lys, L-ornithine [Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.] [ Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.] [ Cloning and characterization of a Family C orphan G-protein coupled receptor.] 926 aa 96515 Da 6q22.1 Calcium-sensing receptor (34%), T1R1 (28%), mGluR1 (24%)
GPRC5D   [Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.] [The RAIG family member, GPRC5D, is associated with hard-keratinized structures.] 345 aa 38791 Da 12p13.3  
GRCA     304 aa or 310 aa [Length of partial sequence] 32963 Da or 33780 Da [MW of partial sequence] 12p13  
LGR6   [The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7.] 828 aa 89302 Da 1q32.1  
LPHN1     1474 aa [Length of unprocessed precursor] 162717 Da [MW of unprocessed precursor] 19p13.2  
LPHN2 (LPHH1)   [Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines.] 1459 aa [Length of unprocessed precursor] 163349 Da [MW of unprocessed precursor] 1p31.1  
LPHN3     1447 aa 161812 Da 4q13.1  
MAS1 (Mas proto-oncogene) Angiotensin-(1-7) [Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas] [G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor.] 325 aa 37465 Da 6q25.3-q26 MAS1L (35%)
MAS1L (MRG)   [Cloning and functional characterization of a novel mas-related gene, modulating intracellular angiotensin II actions.] 378 aa 42411 Da 6p21 MAS1 (35%)
MASS1 (VLGR1)   [Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II.] [Very large G protein-coupled receptor-1, the largest known cell surface protein, is highly expressed in the developing central nervous system.] 6307 aa 692668 Da 5q14  
MRGPRD (MRGD or TGR7 Mas-related G-protein coupled receptor member D) beta-alanine [Identification of a G protein-coupled receptor specifically responsive to beta-alanine.] 321 aa 36118 Da 11q13.3  
MRGX1 (SNSR4 or Mas-related G-protein coupled receptor member X1) BAM8-22 [Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons.] 322 aa 36250 Da 11p15.1  
MRGX2 (Mas-related G-protein coupled receptor member X2) Cortistatin-14 [MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.] 330 aa 37099 Da 11p15.1  
MRGX3 (SNSR1 or Mas-related G-protein coupled receptor member X3)   [Transgenic rats overexpressing the human MrgX3 gene show cataracts and an abnormal skin phenotype.] 322 aa 36484 Da 11p15.1  
MRGX4 (SNSR6 or Mas-related G-protein coupled receptor member X4)   [A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.] 322 aa 36434 Da 11p15.1  
P2Y5 (6H1)   [The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses.] 344 aa 39392 Da 13q14 P2Y10 (32%), GPR55 (29%), GPR92 (40% TM)
P2Y8     359 aa 40635 Da Xp22.33; Yp11.3  
P2Y10 (P2Y-like receptor)   [The Ets factors PU.1 and Spi-B regulate the transcription in vivo of P2Y10, a lymphoid restricted heptahelical receptor.] 339 aa 38774 Da Xq21.1 P2Y5 (32%)
PSGR (OR51E2)   [PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer.] [Quantitative expression profile of PSGR in prostate cancer.] 320 aa 35493 Da 11p15.4 PSGR2 (60%)
PSGR2 (OR51E1 or POGR)   [PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer.] 317 aa 35271 Da 11p15.4 PSGR (60%)
RAIG1 (GPRC5A)   [Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor.] [Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression.] 357 aa 40251 Da 12p13-p12.3 RAIG2 (33%)
RAIG2 (GPRC5B)   [Localisation of the GPRC5B receptor in the rat brain and spinal cord.] [Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain.] 403 aa [Length of unprocessed precursor] 44795 Da [MW of unprocessed precursor] 16p12 RAIG1 (33%)
RAIG3 (GPRC5C)   [Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C).] 441 aa [Length of unprocessed precursor] 48193 Da [MW of unprocessed precursor] 17q25  
TAAR5 (PNR)   [Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain.] 337 aa 38241 Da 6q23.2  
TRAR3 (TA3 or TAAR9)   [Discovery of a null mutation in a human trace amine receptor gene.] 348 aa 39016 Da 6q23.2  
TRAR4 (TA4 or TAAR6)   [Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia.] 345 aa 38451 Da 6q23.2  

For a review of orphan nuclear receptors, check out the following article:
Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V
International Union of Pharmacology. LXVI. Orphan nuclear receptors.
Pharmacol Rev. 2006 Dec;58(4):798-836. [Full Text]

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