Generic Name: Common Chemical Name: Dosage Forms/Routes: Major Metabolite: Database Search Links: |
Initial Approval: Product Insert: Epocrates: Empirical Formula: Molecular Mass: |
Indications: ADHD |
Possible Mechanisms of Action: Dexmethylphenidate inhibits the dopamine transporter and, to a lesser degree, the norepinephrine transporter (1). The drug offers a better therapeutic index than racemic threo-methylphenidate hydrochloride (Ritalin®) (2). |
Chemical Class: |
1. Patrick KS, Caldwell RW, Ferris RM, Breese GR.
Pharmacology of the enantiomers of threo-methylphenidate.
J Pharmacol Exp Ther. 1987 Apr;241(1):152-8. [Abstract]
2. Teo SK, Stirling DI, Thomas SD, Khetani VD.
Neurobehavioral effects of racemic threo-methylphenidate and its D and L enantiomers in rats.
Pharmacol Biochem Behav. 2003 Feb;74(3):747-54. [Abstract]